Older meetings of the CTP network
and research stays of the network members
The data relative to meetings #1 to 5 of this CTP network have been removed from the site, for clarity. The oldest meeting of the CTP network having available descriptive data is the 6th , held in Huesca, Spain, on October 9th, 2009, participating groups from the Universities of Bordeaux 1, Basque Country, Navarra, Zaragoza, Barcelona and Toulouse 3. It was supported by "Communauté de Travail des Pyrénées"
The results presented in the 6th meeting have generated different articles that were published in a special volume of the Journal of Physiology and Biochemistry. These papers showed different aspects related to:
1) Experimental nutrition, performed on laboratory animals. Based on previous observations relative to conjugated polyunsaturated fatty acids, a novel member of this family, namely jacaric acid, has been added to the diet during weeks and its potential use as anti-obesity agent has been assessed in rats (Miranda et al.). In parallel, a study of how short photoperiod could influence lipogenesis and lipolysis and, thus, could be involved in loss of appetite and weight loss, has been performed in Siberian hamsters (Atgié et al). Additionally, novel and recently patented methods for extracting fructose from plant waste reprocessing (apples not suitable to be sold in fruit display) have led to the production of various carbohydrate preparations that have been tested. Their supplementation to standard diet of mice has resulted in beneficial effects regarding glucose handling and insulin resistance (Dray et al.);
2) Adipose tissue metabolism, in humans and animal models. The differential effects of high-fat and high-sucrose diets on the hyperplasia and hypertrophy of adipocytes in the subcutaneous and visceral depots have been studied in obese rats (Boqué et al.), while the metabolic effects of the adipokine visfatin were explored in human subcutaneous adipocytes, focusing on lipolysis and glucose transport activities (Wanecq et al.);
3) Genetic procedures in obesity and insulin resistance. Different genes related to these diseases have been studied, such as the specific lysophosphatidic acid receptor-1, whose invalidation alters food intake in mouse (Dusaulcy et al.), and the pro-inflammatory cytokine interleukin 6, whose -174G/C polymorphism has been repeatedly linked to weight gain, high mortality and celiac disease in man (Moleres et al.); a project focusing on the genes encoding for water and glycerol transporter has also been open to debate.
4) Clinical studies including epidemiological approaches. Healthy effects of dietary components, such as plant sterols, have been examined on cholesterol absorption and metabolism as well as on cardiovascular risk (Sanclemente et al.). A thorough study of fat distribution in obese children and adolescents, its measurement, and its relationship with the metabolic risk has also indicated that currently more than 27 % of this population is obese in Aragon (Revenga et al.). The effects of weight loss on different health aspects, such as iron metabolism and C-reactive protein concentration, have been followed on a period of 6 months and more in overweight subjects with familial combined hyperlipidemia (Mateo-Gallego et al.).
We sincerely acknowledge the support of CTP (www. ctp.org) and the valuable organization of this 6th meeting by I. Marques and T. Sanclemente.
The results presented in the 6th meeting have generated different articles that were published in a special volume of the Journal of Physiology and Biochemistry. These papers showed different aspects related to:
1) Experimental nutrition, performed on laboratory animals. Based on previous observations relative to conjugated polyunsaturated fatty acids, a novel member of this family, namely jacaric acid, has been added to the diet during weeks and its potential use as anti-obesity agent has been assessed in rats (Miranda et al.). In parallel, a study of how short photoperiod could influence lipogenesis and lipolysis and, thus, could be involved in loss of appetite and weight loss, has been performed in Siberian hamsters (Atgié et al). Additionally, novel and recently patented methods for extracting fructose from plant waste reprocessing (apples not suitable to be sold in fruit display) have led to the production of various carbohydrate preparations that have been tested. Their supplementation to standard diet of mice has resulted in beneficial effects regarding glucose handling and insulin resistance (Dray et al.);
2) Adipose tissue metabolism, in humans and animal models. The differential effects of high-fat and high-sucrose diets on the hyperplasia and hypertrophy of adipocytes in the subcutaneous and visceral depots have been studied in obese rats (Boqué et al.), while the metabolic effects of the adipokine visfatin were explored in human subcutaneous adipocytes, focusing on lipolysis and glucose transport activities (Wanecq et al.);
3) Genetic procedures in obesity and insulin resistance. Different genes related to these diseases have been studied, such as the specific lysophosphatidic acid receptor-1, whose invalidation alters food intake in mouse (Dusaulcy et al.), and the pro-inflammatory cytokine interleukin 6, whose -174G/C polymorphism has been repeatedly linked to weight gain, high mortality and celiac disease in man (Moleres et al.); a project focusing on the genes encoding for water and glycerol transporter has also been open to debate.
4) Clinical studies including epidemiological approaches. Healthy effects of dietary components, such as plant sterols, have been examined on cholesterol absorption and metabolism as well as on cardiovascular risk (Sanclemente et al.). A thorough study of fat distribution in obese children and adolescents, its measurement, and its relationship with the metabolic risk has also indicated that currently more than 27 % of this population is obese in Aragon (Revenga et al.). The effects of weight loss on different health aspects, such as iron metabolism and C-reactive protein concentration, have been followed on a period of 6 months and more in overweight subjects with familial combined hyperlipidemia (Mateo-Gallego et al.).
We sincerely acknowledge the support of CTP (www. ctp.org) and the valuable organization of this 6th meeting by I. Marques and T. Sanclemente.
6th meeting held in Huesca
a talk on lack of insulin-like effect of visfatin in human adipose tissue
6th meeting held in Huesca (2)
alteration of food intake in mice lacking LPA-1 receptors
Members of the CTP network at satellite symposium of the II Congress of FESNAD:
The poster presented by:
Josep Mercader, Almudena Lomba, Xavier Brenachot, Fermin I. Milagro, and Christian Carpéné INSERM, U858, Institut de Médecine Moléculaire de Rangueil, IFR 31, 31432 Toulouse, France and Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
Financiado por la Comunidad de Trabajo de los Pirineos y el proyecto DIOmed (SUDOE).
y intitulado:
" Efecto del antidepresivo fenelzina sobre la adiposidad en ratas y sobre la respuesta lipolítica y lipogénica en adipocitos humanos y de roedores "
ha sido premiado como mejor poster en la X edicion del Simposium Nacional de Obesidad, en Reus, 1-2 Marzo 2010
Josep Mercader, Almudena Lomba, Xavier Brenachot, Fermin I. Milagro, and Christian Carpéné INSERM, U858, Institut de Médecine Moléculaire de Rangueil, IFR 31, 31432 Toulouse, France and Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
Financiado por la Comunidad de Trabajo de los Pirineos y el proyecto DIOmed (SUDOE).
y intitulado:
" Efecto del antidepresivo fenelzina sobre la adiposidad en ratas y sobre la respuesta lipolítica y lipogénica en adipocitos humanos y de roedores "
ha sido premiado como mejor poster en la X edicion del Simposium Nacional de Obesidad, en Reus, 1-2 Marzo 2010
Historical picture from the first transnational meeting of the CTP mini-network on obesity and diabetes
Held in Agen, 2003.
Continuing research stays accross the Pyrénées, related to research on metabolic diseases
In 2015, Fran Les moved from Villanueva de Gallego to Toulouse.
In 2012, Marta Fernandez Galilea from Pamplona, spent 4 months in Toulouse I2MC, team 4.
In 2010-2011,Ana Gomez-Ruiz, from Pamplona, & Josep Mercader, from Palma de Majorca, were in post-doc stays In Toulouse, working on the DIOMED project,
Saioa Gomez Zorita, student from the University of Pais Vasco was in stay at I2MC, team 3 in Toulouse for 4 months in late 2011.
Before, a stay of Aurelia Heniquez from Toulouse to Barcelona also succeeded in a common publication between catalan and occitan teams.
Students from the IACS or from the San Jorge Univ (Zaragoza) also spent short stays at I2MC in Toulouse, while among the pioneers of such transborder exchanges was Luc Marti, moving from Toulouse to GenMedica in Barcelona, and Jéremie Boucher , moving from Toulouse to Salamanca at the beginning of the millenium, without taking into account the numerous stays of Christian Carpéné in Madrid, Salamanca, Valladolid, Barcelona, Vitoria, Pamplona, in the continituy of the relationships raised by Don P. Montastruc and Don Garcia de Jàlon in the 80s.
In 2012, Marta Fernandez Galilea from Pamplona, spent 4 months in Toulouse I2MC, team 4.
In 2010-2011,Ana Gomez-Ruiz, from Pamplona, & Josep Mercader, from Palma de Majorca, were in post-doc stays In Toulouse, working on the DIOMED project,
Saioa Gomez Zorita, student from the University of Pais Vasco was in stay at I2MC, team 3 in Toulouse for 4 months in late 2011.
Before, a stay of Aurelia Heniquez from Toulouse to Barcelona also succeeded in a common publication between catalan and occitan teams.
Students from the IACS or from the San Jorge Univ (Zaragoza) also spent short stays at I2MC in Toulouse, while among the pioneers of such transborder exchanges was Luc Marti, moving from Toulouse to GenMedica in Barcelona, and Jéremie Boucher , moving from Toulouse to Salamanca at the beginning of the millenium, without taking into account the numerous stays of Christian Carpéné in Madrid, Salamanca, Valladolid, Barcelona, Vitoria, Pamplona, in the continituy of the relationships raised by Don P. Montastruc and Don Garcia de Jàlon in the 80s.
Screening of novel molecules interacting with amine oxidases for discovery of anti-diabetic or anti-obesity drugs
The Head of the DIOMED european project, granted by INTERRREG IVB, was Antonio Zorzano, an eminent member of the CTPIOD minired.
Part of the research was performed until 2011 in labs that are also coworking via the CTPIOD network:
INSERM U 1048, Toulouse
Dpt Bioquimica Biol Molec, Univ Barcelona
and labs from: Porto, Santiago de Compostella
The Head of the DIOMED european project, granted by INTERRREG IVB, was Antonio Zorzano, an eminent member of the CTPIOD minired.
Part of the research was performed until 2011 in labs that are also coworking via the CTPIOD network:
INSERM U 1048, Toulouse
Dpt Bioquimica Biol Molec, Univ Barcelona
and labs from: Porto, Santiago de Compostella