Welcome to:
Potential role of mediterranean diet components in the treatments of obesity, hyperlipidaemia and diabetes
Rôle potentiel de la diète méditerranéenne dans les traitements anti-obésité, anti-hyperlipidémie ou anti-diabète
Interés de la dieta mediterránea en los tratamientos de la obesidad, diabetes e hiperlipidemia
Potencial de l'alimentació mediterrània dins el tractament de la obesitat, diabetes i hiperlipidèmia
Mediterranear dietaren garrantzi obesitatearen, diabetearen eta hiperlipidemiaren aurkako tratamenduan
www.Obesitydiabetesinctp.weebly.com
Aim of our CTP network
Context
The health conditions present worldwide and in the border regions of Pyrénées are at the origins of the present network. The fight against obesity and diabetes is a priority in all Western societies and also relates to Andorra, Aquitaine, Aragon, Catalunya, Euskadi, Languedoc-Roussillon, Midi-Pyrénées and Navarra, since these metabolic disorders are steadily increasing whatever the geographic location. Thus, the prevalence of obesity is greater than 25% in numerous countries from the Southern (Italy, Spain, Portugal, Cyprus) and Eastern Europe (Poland, the Czech Republic, Romania, Albania) (1). In a NHANES survey from 2004 (12), prevalence in the USA ranged from 29% in white men to 50% in black women. More details and update of the obesity epidemics can be found at the website of the International Association for the Study of Obesity (http://www.iaso.org). On the other hand, the number of diabetic patients is 52.3 million in Europe, and as for obesity, its prevalence will increase between 8 and 13% over the next few years (9). It has been estimated that in 2030, diabetes will be the fourth leading cause of death in developed countries after ischemic heart disease, cerebrovascular disease and cancer. Consequently, the fight against cardiovascular disease and diabetes, the major complications of obesity, is definitively among the priorities of biomedical investigations in Europe as well as in other continents. This has been taken into account in the 7th Framework Program of the European Union. (FP7 Cooperation-Health) but others funds and cooperative projects have also considerably participated to such issue. The “metabolic diseases” are influenced by the genetic background and different environmental factors, such as sedentarism, food habits, or energy-dense foods, which undoubtedly predispose to suffer metabolic diseases (6). In spite of the numerous public health campaigns and interventions, mainly based on lifestyle improvement advices, the increasing prevalence of obesity and diabetes has not dropped significantly, and their indirect costs remain elevated. In this alarming context, the search for novel therapeutic interventions for diabetes, obesity and dyslipidemias (either by nutritional or pharmacological approaches) is of outmost importance. Different diets and food components have been repeatedly linked to important health benefits. Indeed, the preventive role of the Mediterranean diet in the development of obesity, type 2 diabetes and cardiovascular diseases (11) has been widely studied, but novel insights remain to be depicted. Undeniably, individual nutritional factors have demonstrated interesting healthy effects, such as omega 3 fatty acids (8), conjugated linoleic acid (5), non-digestible carbohydrates (2), or vitamins (3, 10). Other candidates as nutritional supplements are under exploration such as dietary amines (4) or fiber components (7). Noteworthy, French and Spanish research teams have actively participated in all these investigations.
About the aim of the network
In this context, a scientific network, called "Potential role of Mediterranean diet components in the treatments of obesity, hyperlipidaemias and diabetes", has been dealing since 2003 with the objective of sharing knowledge among these different French and Spanish teams studying Nutrition and Metabolism. The main goal of this network is to promote cross-border collaboration between the different groups involved and to exchange information on nutrition and regulation of energy metabolism by molecules present in food. While separated by less than 1000 km, the different investigators of this network have sometimes more difficulties to meet each other as a consequence of the Pyrénées mountains which separate in two halves (North and South ) the CTP area.
An added value of this network is the scientific cooperation between the Spanish and French teams participating in it. Indeed, the technology exchange among the respective teams (eight at the present time) and the improvement of complementary research strategies have resulted in more than 28 scientific publications in the period 2003-2011 involving collaboration of at least two partners on the network. Moreover more than 70 communications have been presented by/to the partners of the network since 2003; most of them have been published in the Journal of Physiology and Biochemistry (including 7 reviews).
In the future, we want to strengthen our cooperations and improve our common knowledge about the nutritional prevention and the pharmacological treatment of obesity, diabetes and their related complications.
References
1. Berghöfer, A., Pischon, T., Reinhold, T., Apovian, C. M., Sharma, A. M., Willich, S. N. (2008): Obesity prevalence from a European perspective: a systematic review. BMC Public Health, 8, 200.
2. Boucher, J., Daviaud, D., Siméon-Remaud, M., Carpéné, C., Saulnier-Blache, J.S., Monsan, P., Valet, P. (2003): Effect of non-digestible gluco-oligosaccharides on glucose sensitivity in high fat diet fed mice. J Physiol Biochem, 59, 169-173.
3. Campión, J., Milagro, F. I., Fernández, D., Martínez, J. A. (2006): Differential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity. J Physiol Biochem, 62, 71-80.
4. Carpéné, C., Bour, S., Visentin, V., Pellati, F., Benvenuti, S., Iglesias-Osma, M. C., Garcia-Barrado, M. J., Valet, P. (2005): Amine oxidase substrates for impaired glucose tolerance correction. J. Physiol. Biochem., 61, 405-420.
5. Lasa, A., Simón, E., Churruca, I., Fernández-Quintela, A., Rodríguez, V.M., Portillo, M. P. (2007): Adiposity and serum parameters in hamsters fed energy restricted diets supplemented or not with trans-10,cis-12 conjugated linoleic acid. J Physiol Biochem., 63, 297-304.
6. Marti, A., Martinez-González, M. A., Martinez, J. A. (2008): Interaction between genes and lifestyle factors on obesity. Proc Nutr Soc, 67, 1-8.
7. Moreno, L. A., Tresaco, B., Bueno, G., Fleta, J., Rodríguez, G., Garagorri, J. M., Bueno, M. (2003): Psyllium fibre and the metabolic control of obese children and adolescents. J Physiol Biochem., 59, 235-242.
8. Parra, D., Ramel, A., Bandarra, N., Kiely, M., Martínez, J. A., Thorsdottir, I. (2008): A diet rich in long chain omega-3 fatty acids modulates satiety in overweight and obese volunteers during weight loss. Appetite, 51, 676-680.
9. Passa, P. (2002): Diabetes trends in Europe. Diabetes Metab Res Rev, 18 Suppl 3, S3-8.
10. Redonnet, A., Ferrand, C., Bairras, C., Higueret, P., Noël-Suberville, C., Cassand, P., Atgié, C. (2008): Synergic effect of vitamin A and high-fat diet in adipose tissue development and nuclear receptor expression in young rats. Br J Nutr, 100, 722-730.
11. Urquiaga, I., Echeverría, G., Polic, G., Castillo, O., Liberona, Y., Rozowski, J., Perez, D., Martinez, C., Vasquez, L., Strobel, P., Mezzano, D., Leighton, F. (2008): Mediterranean food and diets, global resource for the control of metabolic syndrome and chronic diseases. World Rev Nutr Diet, 98, 150-173.
12. Wang, Y. C., Colditz, G. A., Kuntz, K. M. (2007): Forecasting the obesity epidemic in the aging U.S. population. Obesity, 15, 2855-2865.
any additionnal information could be requested at: christian.carpene.inserm.fr
